| Team | P | W | D | L | F | A | F-A | TBP | LBP | BP | Pts |
| Leicester Tigers | 22 | 16 | 1 | 5 | 594 | 403 | +191 | 8 | 4 | 12 | 78 |
| Saracens | 22 | 18 | 0 | 4 | 484 | 318 | +166 | 2 | 2 | 4 | 76 |
| Gloucester Rugby | 22 | 14 | 1 | 7 | 528 | 452 | +76 | 5 | 4 | 9 | 67 |
| Northampton Saints | 22 | 14 | 0 | 8 | 533 | 430 | +103 | 6 | 3 | 9 | 65 |
| Bath Rugby | 22 | 13 | 1 | 8 | 427 | 367 | +60 | 5 | 3 | 8 | 62 |
| London Irish | 22 | 11 | 0 | 11 | 523 | 459 | +64 | 6 | 4 | 10 | 54 |
| Harlequins | 22 | 9 | 2 | 11 | 482 | 384 | +98 | 4 | 8 | 12 | 52 |
| Exeter Chiefs | 22 | 10 | 0 | 12 | 428 | 460 | -32 | 0 | 5 | 5 | 43 |
| London Wasps | 22 | 9 | 1 | 12 | 425 | 497 | -72 | 1 | 4 | 5 | 43 |
| Sale Sharks | 22 | 6 | 1 | 15 | 432 | 618 | -186 | 1 | 5 | 6 | 32 |
| Newcastle Falcons | 22 | 4 | 1 | 17 | 360 | 553 | -193 | 0 | 5 | 5 | 23 |
| Leeds Carnegie | 22 | 4 | 0 | 18 | 315 | 590 | -275 | 0 | 7 | 7 | 23 |
In the case of equality at any stage of the season, positions at that stage of the season shall be determined firstly by the number of wins achieved and then on the basis of match points differential. A club with a larger number of wins shall be placed higher than a club with the same number of league points but fewer wins.
If clubs have equal league points and equal number of wins then a club with a larger difference between match points "for" and match points "against" shall be placed higher in the Premiership League than a club with a smaller difference between match points "for" and match points "against".
Should two clubs have the same number of league points and the same match points difference, the club having scored more match points "for" shall be placed higher in the Premiership League than the club having the lesser number of match points "for".
If the above does not establish different Premiership League positions then the club in the higher position shall be the club that has achieved the higher aggregate match points scored by it in the same season against the other club.
If this still does not establish the position then the club who has won the most matches, excluding its first Premiership League match of the season, then its second Premiership League match and so on, until it can be established which the higher placed club is.
| Result Date | Team | Pts | Team | Pts | |||
| 3 Sep 2010 | Sale Sharks | 4 | Newcastle Falcons | 0 | Table | Match | ||
| 4 Sep 2010 | London Irish | 5 | Saracens | 0 | Table | Match | ||
| Exeter Chiefs | 4 | Gloucester Rugby | 0 | Match | |||
| London Wasps | 2 | Harlequins | 2 | Match | |||
| 5 Sep 2010 | Bath Rugby | 5 | Leeds Carnegie | 0 | Table | Match | ||
| Northampton Saints | 4 | Leicester Tigers | 0 | Match | |||
| 10 Sep 2010 | Newcastle Falcons | 4 | London Wasps | 0 | Table | Match | ||
| 11 Sep 2010 | Northampton Saints | 4 | Harlequins | 1 | Table | Match | ||
| Bath Rugby | 4 | London Irish | 1 | Match | |||
| Gloucester Rugby | 4 | Leeds Carnegie | 1 | Match | |||
| Leicester Tigers | 5 | Exeter Chiefs | 0 | Match | |||
| 12 Sep 2010 | Saracens | 4 | Sale Sharks | 0 | Table | Match | ||
| 17 Sep 2010 | Northampton Saints | 5 | Bath Rugby | 0 | Table | Match | ||
| Sale Sharks | 4 | Harlequins | 1 | Match | |||
| 18 Sep 2010 | Exeter Chiefs | 4 | Newcastle Falcons | 1 | Table | Match | ||
| London Wasps | 4 | Leicester Tigers | 2 | Match | |||
| 19 Sep 2010 | Saracens | 4 | Leeds Carnegie | 0 | Table | Match | ||
| London Irish | 4 | Gloucester Rugby | 1 | Match | |||
| 25 Sep 2010 | Bath Rugby | 5 | Sale Sharks | 0 | Table | Match | ||
| Gloucester Rugby | 4 | London Wasps | 1 | Match | |||
| Harlequins | 5 | Exeter Chiefs | 0 | Match | |||
| Leicester Tigers | 5 | Leeds Carnegie | 0 | Match | |||
| London Irish | 5 | Newcastle Falcons | 0 | Match | |||
| 26 Sep 2010 | Saracens | 4 | Northampton Saints | 1 | Table | Match | ||
| 1 Oct 2010 | London Wasps | 4 | Sale Sharks | 1 | Table | Match | ||
| Gloucester Rugby | 4 | Bath Rugby | 0 | Match | |||
| 2 Oct 2010 | Harlequins | 4 | Newcastle Falcons | 0 | Table | Match | ||
| London Irish | 5 | Leeds Carnegie | 0 | Match | |||
| Northampton Saints | 4 | Exeter Chiefs | 1 | Match | |||
| 3 Oct 2010 | Saracens | 4 | Leicester Tigers | 1 | Table | Match | ||
| 22 Oct 2010 | Sale Sharks | 4 | Leeds Carnegie | 1 | Table | Match | ||
| Saracens | 4 | Newcastle Falcons | 1 | Match | |||
| 23 Oct 2010 | Leicester Tigers | 4 | Bath Rugby | 1 | Table | Match | ||
| Gloucester Rugby | 4 | Harlequins | 1 | Match | |||
| London Irish | 4 | Exeter Chiefs | 1 | Match | |||
| 24 Oct 2010 | Northampton Saints | 5 | London Wasps | 0 | Table | Match | ||
| 30 Oct 2010 | Northampton Saints | 5 | Newcastle Falcons | 0 | Table | Match | ||
| Exeter Chiefs | 4 | Saracens | 0 | Match | |||
| Gloucester Rugby | 4 | Leicester Tigers | 1 | Match | |||
| 31 Oct 2010 | Harlequins | 2 | Bath Rugby | 2 | Table | Match | ||
| London Wasps | 4 | Leeds Carnegie | 0 | Match | |||
| London Irish | 5 | Sale Sharks | 0 | Match | |||
| 19 Nov 2010 | Leicester Tigers | 4 | Harlequins | 1 | Table | Match | ||
| Northampton Saints | 4 | Sale Sharks | 0 | Match | |||
| 20 Nov 2010 | Exeter Chiefs | 4 | Leeds Carnegie | 1 | Table | Match | ||
| 21 Nov 2010 | London Wasps | 4 | London Irish | 0 | Table | Match | ||
| Newcastle Falcons | 4 | Gloucester Rugby | 1 | Match | |||
| Saracens | 4 | Bath Rugby | 1 | Match | |||
| 26 Nov 2010 | Northampton Saints | 5 | London Irish | 0 | Table | Match | ||
| 27 Nov 2010 | Exeter Chiefs | 4 | Sale Sharks | 1 | Table | Match | ||
| Leicester Tigers | 5 | Newcastle Falcons | 0 | Match | |||
| Gloucester Rugby | 4 | Saracens | 1 | Match | |||
| London Wasps | 4 | Bath Rugby | 1 | Match | |||
| 28 Nov 2010 | Harlequins | 5 | Leeds Carnegie | 0 | Table | Match | ||
| 4 Dec 2010 | Leicester Tigers | 4 | London Irish | 0 | Table | Match | ||
| 5 Dec 2010 | Saracens | 4 | Harlequins | 0 | Table | Match | ||
| London Wasps | 4 | Exeter Chiefs | 0 | Match | |||
| 26 Dec 2010 | Saracens | 4 | London Wasps | 1 | Table | Match | ||
| 27 Dec 2010 | Leicester Tigers | 5 | Sale Sharks | 0 | Table | Match | ||
| Harlequins | 4 | London Irish | 0 | Match | |||
| 1 Jan 2011 | Leeds Carnegie | 4 | Gloucester Rugby | 1 | Table | Match | ||
| Harlequins | 4 | Northampton Saints | 1 | Match | |||
| Bath Rugby | 4 | London Irish | 1 | Match | |||
| 2 Jan 2011 | Sale Sharks | 4 | Saracens | 1 | Table | Match | ||
| London Wasps | 4 | Newcastle Falcons | 0 | Match | |||
| Leicester Tigers | 4 | Exeter Chiefs | 1 | Match | |||
| 7 Jan 2011 | Newcastle Falcons | 2 | Sale Sharks | 2 | Table | Match | ||
| 8 Jan 2011 | Bath Rugby | 4 | Leeds Carnegie | 1 | Table | Match | ||
| Harlequins | 4 | London Wasps | 1 | Match | |||
| Gloucester Rugby | 5 | Exeter Chiefs | 0 | Match | |||
| Leicester Tigers | 4 | Northampton Saints | 0 | Match | |||
| 9 Jan 2011 | Saracens | 4 | London Irish | 1 | Table | Match | ||
| 11 Feb 2011 | Bath Rugby | 4 | Sale Sharks | 0 | Table | Match | ||
| 12 Feb 2011 | London Irish | 4 | Newcastle Falcons | 0 | Table | Match | ||
| Saracens | 4 | Northampton Saints | 0 | Match | |||
| Exeter Chiefs | 4 | Harlequins | 0 | Match | |||
| 13 Feb 2011 | Leicester Tigers | 4 | Leeds Carnegie | 1 | Table | Match | ||
| Gloucester Rugby | 4 | London Wasps | 1 | Match | |||
| 18 Feb 2011 | Gloucester Rugby | 4 | London Irish | 0 | Table | Match | ||
| Exeter Chiefs | 4 | Newcastle Falcons | 0 | Match | |||
| 19 Feb 2011 | Harlequins | 4 | Sale Sharks | 0 | Table | Match | ||
| Bath Rugby | 5 | Northampton Saints | 0 | Match | |||
| Leicester Tigers | 4 | London Wasps | 0 | Match | |||
| 20 Feb 2011 | Saracens | 5 | Leeds Carnegie | 0 | Table | Match | ||
| 25 Feb 2011 | Leicester Tigers | 4 | Sale Sharks | 1 | Table | Match | ||
| 26 Feb 2011 | London Irish | 4 | Harlequins | 1 | Table | Match | ||
| Gloucester Rugby | 4 | Northampton Saints | 1 | Match | |||
| Bath Rugby | 4 | Exeter Chiefs | 1 | Match | |||
| 27 Feb 2011 | Saracens | 4 | London Wasps | 0 | Table | Match | ||
| Newcastle Falcons | 4 | Leeds Carnegie | 0 | Match | |||
| 4 Mar 2011 | Newcastle Falcons | 4 | Harlequins | 0 | Table | Match | ||
| 5 Mar 2011 | Gloucester Rugby | 5 | Bath Rugby | 0 | Table | Match | ||
| Saracens | 4 | Leicester Tigers | 1 | Match | |||
| 6 Mar 2011 | Exeter Chiefs | 4 | Northampton Saints | 0 | Table | Match | ||
| Leeds Carnegie | 4 | London Irish | 0 | Match | |||
| London Wasps | 4 | Sale Sharks | 1 | Match | |||
| 12 Mar 2011 | Northampton Saints | 4 | Leeds Carnegie | 0 | Table | Match | ||
| 25 Mar 2011 | Sale Sharks | 4 | Leeds Carnegie | 1 | Table | Match | ||
| 26 Mar 2011 | Harlequins | 5 | Gloucester Rugby | 0 | Table | Match | ||
| London Irish | 5 | Exeter Chiefs | 0 | Match | |||
| Leicester Tigers | 5 | Bath Rugby | 0 | Match | |||
| 27 Mar 2011 | Northampton Saints | 5 | London Wasps | 0 | Table | Match | ||
| Saracens | 4 | Newcastle Falcons | 0 | Match | |||
| 2 Apr 2011 | Northampton Saints | 5 | Sale Sharks | 0 | Table | Match | ||
| Gloucester Rugby | 5 | Newcastle Falcons | 0 | Match | |||
| Leicester Tigers | 4 | Harlequins | 1 | Match | |||
| 3 Apr 2011 | Saracens | 4 | Bath Rugby | 0 | Table | Match | ||
| Leeds Carnegie | 4 | Exeter Chiefs | -1 | Match | |||
| London Irish | 4 | London Wasps | 0 | Match | |||
| 8 Apr 2011 | Sale Sharks | 5 | Gloucester Rugby | 1 | Table | Match | ||
| 9 Apr 2011 | Bath Rugby | 4 | Exeter Chiefs | 0 | Table | Match | ||
| Leeds Carnegie | 4 | Newcastle Falcons | 1 | Match | |||
| 15 Apr 2011 | Northampton Saints | 4 | Newcastle Falcons | 1 | Table | Match | ||
| 16 Apr 2011 | Bath Rugby | 4 | Harlequins | 1 | Table | Match | ||
| Saracens | 4 | Exeter Chiefs | 0 | Match | |||
| Leicester Tigers | 3 | Gloucester Rugby | 3 | Match | |||
| London Irish | 5 | Sale Sharks | 0 | Match | |||
| 17 Apr 2011 | London Wasps | 5 | Leeds Carnegie | 0 | Table | Match | ||
| 19 Apr 2011 | Gloucester Rugby | 4 | Northampton Saints | 0 | Table | Match | ||
| 22 Apr 2011 | Exeter Chiefs | 4 | Sale Sharks | 1 | Table | Match | ||
| Leicester Tigers | 4 | Newcastle Falcons | 0 | Match | |||
| 23 Apr 2011 | Northampton Saints | 4 | London Irish | 1 | Table | Match | ||
| Bath Rugby | 5 | London Wasps | 0 | Match | |||
| 24 Apr 2011 | Saracens | 5 | Gloucester Rugby | 0 | Table | Match | ||
| Harlequins | 5 | Leeds Carnegie | 0 | Match | |||
| 30 Apr 2011 | Bath Rugby | 4 | Newcastle Falcons | 1 | Table | Match | ||
| 7 May 2011 | Bath Rugby | 5 | Newcastle Falcons | 0 | Table | Match | ||
| Exeter Chiefs | 4 | London Wasps | 0 | Match | |||
| Gloucester Rugby | 5 | Sale Sharks | 0 | Match | |||
| Saracens | 4 | Harlequins | 1 | Match | |||
| Leicester Tigers | 5 | London Irish | 0 | Match | |||
| Northampton Saints | 4 | Leeds Carnegie | 1 | Match |
