| Team | P | W | D | L | F | A | F-A | TBP | LBP | BP | Pts |
| Leicester Tigers | 12 | 8 | 0 | 4 | 348 | 239 | +109 | 5 | 3 | 8 | 40 |
| Northampton Saints | 10 | 8 | 0 | 2 | 260 | 162 | +98 | 4 | 2 | 6 | 38 |
| Saracens | 12 | 8 | 0 | 4 | 235 | 213 | +22 | 0 | 2 | 2 | 34 |
| London Wasps | 12 | 7 | 1 | 4 | 262 | 251 | +11 | 0 | 2 | 2 | 32 |
| London Irish | 12 | 6 | 0 | 6 | 310 | 267 | +43 | 4 | 2 | 6 | 30 |
| Harlequins | 12 | 5 | 2 | 5 | 279 | 227 | +52 | 2 | 4 | 6 | 30 |
| Gloucester Rugby | 10 | 6 | 0 | 4 | 178 | 167 | +11 | 0 | 3 | 3 | 27 |
| Exeter Chiefs | 11 | 5 | 0 | 6 | 203 | 226 | -23 | 0 | 3 | 3 | 23 |
| Bath Rugby | 10 | 4 | 1 | 5 | 161 | 173 | -12 | 2 | 3 | 5 | 23 |
| Sale Sharks | 12 | 4 | 1 | 7 | 238 | 299 | -61 | 0 | 2 | 2 | 20 |
| Newcastle Falcons | 11 | 2 | 1 | 8 | 180 | 294 | -114 | 0 | 2 | 2 | 12 |
| Leeds Carnegie | 10 | 1 | 0 | 9 | 134 | 270 | -136 | 0 | 3 | 3 | 7 |
In the case of equality at any stage of the season, positions at that stage of the season shall be determined firstly by the number of wins achieved and then on the basis of match points differential. A club with a larger number of wins shall be placed higher than a club with the same number of league points but fewer wins.
If clubs have equal league points and equal number of wins then a club with a larger difference between match points "for" and match points "against" shall be placed higher in the Premiership League than a club with a smaller difference between match points "for" and match points "against".
Should two clubs have the same number of league points and the same match points difference, the club having scored more match points "for" shall be placed higher in the Premiership League than the club having the lesser number of match points "for".
If the above does not establish different Premiership League positions then the club in the higher position shall be the club that has achieved the higher aggregate match points scored by it in the same season against the other club.
If this still does not establish the position then the club who has won the most matches, excluding its first Premiership League match of the season, then its second Premiership League match and so on, until it can be established which the higher placed club is.
| Result Date | Team | Pts | Team | Pts | |||
| 3 Sep 2010 | Sale Sharks | 4 | Newcastle Falcons | 0 | Table | Match | ||
| 4 Sep 2010 | London Irish | 5 | Saracens | 0 | Table | Match | ||
| Exeter Chiefs | 4 | Gloucester Rugby | 0 | Match | |||
| London Wasps | 2 | Harlequins | 2 | Match | |||
| 5 Sep 2010 | Bath Rugby | 5 | Leeds Carnegie | 0 | Table | Match | ||
| Northampton Saints | 4 | Leicester Tigers | 0 | Match | |||
| 10 Sep 2010 | Newcastle Falcons | 4 | London Wasps | 0 | Table | Match | ||
| 11 Sep 2010 | Northampton Saints | 4 | Harlequins | 1 | Table | Match | ||
| Bath Rugby | 4 | London Irish | 1 | Match | |||
| Gloucester Rugby | 4 | Leeds Carnegie | 1 | Match | |||
| Leicester Tigers | 5 | Exeter Chiefs | 0 | Match | |||
| 12 Sep 2010 | Saracens | 4 | Sale Sharks | 0 | Table | Match | ||
| 17 Sep 2010 | Northampton Saints | 5 | Bath Rugby | 0 | Table | Match | ||
| Sale Sharks | 4 | Harlequins | 1 | Match | |||
| 18 Sep 2010 | Exeter Chiefs | 4 | Newcastle Falcons | 1 | Table | Match | ||
| London Wasps | 4 | Leicester Tigers | 2 | Match | |||
| 19 Sep 2010 | Saracens | 4 | Leeds Carnegie | 0 | Table | Match | ||
| London Irish | 4 | Gloucester Rugby | 1 | Match | |||
| 25 Sep 2010 | Bath Rugby | 5 | Sale Sharks | 0 | Table | Match | ||
| Gloucester Rugby | 4 | London Wasps | 1 | Match | |||
| Harlequins | 5 | Exeter Chiefs | 0 | Match | |||
| Leicester Tigers | 5 | Leeds Carnegie | 0 | Match | |||
| London Irish | 5 | Newcastle Falcons | 0 | Match | |||
| 26 Sep 2010 | Saracens | 4 | Northampton Saints | 1 | Table | Match | ||
| 1 Oct 2010 | London Wasps | 4 | Sale Sharks | 1 | Table | Match | ||
| Gloucester Rugby | 4 | Bath Rugby | 0 | Match | |||
| 2 Oct 2010 | Harlequins | 4 | Newcastle Falcons | 0 | Table | Match | ||
| London Irish | 5 | Leeds Carnegie | 0 | Match | |||
| Northampton Saints | 4 | Exeter Chiefs | 1 | Match | |||
| 3 Oct 2010 | Saracens | 4 | Leicester Tigers | 1 | Table | Match | ||
| 22 Oct 2010 | Sale Sharks | 4 | Leeds Carnegie | 1 | Table | Match | ||
| Saracens | 4 | Newcastle Falcons | 1 | Match | |||
| 23 Oct 2010 | Leicester Tigers | 4 | Bath Rugby | 1 | Table | Match | ||
| Gloucester Rugby | 4 | Harlequins | 1 | Match | |||
| London Irish | 4 | Exeter Chiefs | 1 | Match | |||
| 24 Oct 2010 | Northampton Saints | 5 | London Wasps | 0 | Table | Match | ||
| 30 Oct 2010 | Northampton Saints | 5 | Newcastle Falcons | 0 | Table | Match | ||
| Exeter Chiefs | 4 | Saracens | 0 | Match | |||
| Gloucester Rugby | 4 | Leicester Tigers | 1 | Match | |||
| 31 Oct 2010 | Harlequins | 2 | Bath Rugby | 2 | Table | Match | ||
| London Wasps | 4 | Leeds Carnegie | 0 | Match | |||
| London Irish | 5 | Sale Sharks | 0 | Match | |||
| 19 Nov 2010 | Leicester Tigers | 4 | Harlequins | 1 | Table | Match | ||
| Northampton Saints | 4 | Sale Sharks | 0 | Match | |||
| 20 Nov 2010 | Exeter Chiefs | 4 | Leeds Carnegie | 1 | Table | Match | ||
| 21 Nov 2010 | London Wasps | 4 | London Irish | 0 | Table | Match | ||
| Newcastle Falcons | 4 | Gloucester Rugby | 1 | Match | |||
| Saracens | 4 | Bath Rugby | 1 | Match | |||
| 26 Nov 2010 | Northampton Saints | 5 | London Irish | 0 | Table | Match | ||
| 27 Nov 2010 | Exeter Chiefs | 4 | Sale Sharks | 1 | Table | Match | ||
| Leicester Tigers | 5 | Newcastle Falcons | 0 | Match | |||
| Gloucester Rugby | 4 | Saracens | 1 | Match | |||
| London Wasps | 4 | Bath Rugby | 1 | Match | |||
| 28 Nov 2010 | Harlequins | 5 | Leeds Carnegie | 0 | Table | Match | ||
| 4 Dec 2010 | Leicester Tigers | 4 | London Irish | 0 | Table | Match | ||
| 5 Dec 2010 | Saracens | 4 | Harlequins | 0 | Table | Match | ||
| London Wasps | 4 | Exeter Chiefs | 0 | Match | |||
| 26 Dec 2010 | Saracens | 4 | London Wasps | 1 | Table | Match | ||
| 27 Dec 2010 | Leicester Tigers | 5 | Sale Sharks | 0 | Table | Match | ||
| Harlequins | 4 | London Irish | 0 | Match | |||
| 1 Jan 2011 | Leeds Carnegie | 4 | Gloucester Rugby | 1 | Table | Match | ||
| Harlequins | 4 | Northampton Saints | 1 | Match | |||
| Bath Rugby | 4 | London Irish | 1 | Match | |||
| 2 Jan 2011 | Sale Sharks | 4 | Saracens | 1 | Table | Match | ||
| London Wasps | 4 | Newcastle Falcons | 0 | Match | |||
| Leicester Tigers | 4 | Exeter Chiefs | 1 | Match | |||
| 7 Jan 2011 | Newcastle Falcons | 2 | Sale Sharks | 2 | Table | Match |
